产品概述
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NanoSIMS 50L能同时提供关键性能，而使用任何其他已知的仪器或技术只能部分提供这些性能：
高分析空间分辨率（低至50纳米）
高灵敏度（元素成像中的ppm）
高质量分辨率（M/dM）
并行采集七种不同质荷比离子
快速采集（直流模式，不发生脉冲）
能够分析电绝缘样品
经过改良，现在可实现千分之十几的同位素比值再现性。
扩展应用领域
微生物学：
NanoSIMS 50L为环境中混合微生物群落研究中的单细胞系统发育特征（使用FISH或El-FISH）和代谢功能（使用稳定同位素标记）的结合开辟了新的可能性。
细胞生物学：
NanoSIMS 50L具备50纳米分辨率和测定同位素比值功能，可实现对细胞内带有稳定同位素标记的分子的积累和传输的测量。
地质学和空间科学：
NanoSIMS 50L可以对行星际尘埃颗粒、陨石和矿物部分的亚微米区域、晶粒或包裹体进行精确的同位素和元素测量。该仪器在多个法拉第杯配置下工作，并具有几微米的光斑尺寸，可以提供同位素比值测量，具有极高精确度以及低至千分之十几的的外部再现性。
材料研究：
凭借高质量分辨率下的高灵敏度（无质量干扰），即使在电绝缘材料中，NanoSIMS 50L也可以在50纳米SIMS横向分辨率下进行痕量元素（掺杂物）成像和定量分析。除稀有气体以外的所有元素（从氢到钚）均可测量。
NanoSIMS 50L最初由法国巴黎第十一大学的G. Slodzian教授设计。
看看NanoSIMS能够做什么
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火山学：岩浆冷却和冷藏（NanoSIMS）
NanoSIMS可用于获取痕量元素线扫描（光斑尺寸为500或1000纳米）和比较锆石晶体中的模型扩散分布，有助于分析火山岩浆的冷却和储存条件。
继续阅读
生物地球化学：细胞外生物矿化的分析（NanoSIMS）
NanoSIMS元素分布图兼具高横向分辨率和高灵敏度，证实了蛋白质与生物纳米晶体之间的关联，这是细胞外生物矿化的一个例子。
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环境微生物学：厌氧光合细菌生态生理学（NanoSIMS）
微生物学家可使用NanoSIMS量化个体微生物在其环境中的代谢活性和相互作用(无需培养)。
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微生物海洋学：量化微生物对碳和氮循环的贡献（NanoSIMS）
NanoSIMS用于量化自由活细胞以及浮游植物细菌聚集体对碳和氮的吸收，这对于了解它们对预计的海洋变暖的反应至关重要。
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黄铁矿中的不可见金（NanoSIMS）
NanoSIMS具备独特功能，能够以高灵敏度和高横向分辨率对痕量元素中的硫同位素比值进行映射，从而揭示黄铁矿中连续的富金流体包裹体。
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锆合金的氧化行为（NanoSIMS）
同位素示踪剂通过NanoSIMS对表面附近的横截面成像来揭示活性氧化位点。即使在低浓度下，NanoSIMS也是用于映射轻元素（B、2H）的优选工具。
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贵金属纳米结构的生长（NanoSIMS）
NanoSIMS可用于研究等离子体驱动的金纳米棱柱合成，有助于阐明单纳米颗粒水平下光化学生长机制的细节。
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多晶材料的偏析和扩散（NanoSIMS）
NanoSIMS兼具高灵敏度和高空间分辨率，用于研究复杂材料中元素的偏析和扩散。
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细胞生物学：干细胞分裂量化（NanoSIMS）
为测试永生化链假说，使用NanoSIMS进行关于稳定同位素标记和定量多同位素质谱的实验。
继续阅读
细胞生物学：蛋白质周转（NanoSIMS）
NanoSIMS可帮助生物学家查看和量化蛋白质周转数据并在细胞内分辨率水平上追踪生物分子的命运。
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下载文档
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应用 - Understanding Aging & Cell Regeneration
应用 - Environmental Microbiology
小册子 - Instrumentation（中文）
小册子 - Instrumentation
小册子 - Materials
小册子 - Cell Biology
传单 - Materials and Geosciences
传单 - Environmental Microbiology
传单 - Cell Biology
Success story – Carsten Müller: Scoping out soils
Success story - Advanced geobiology answers at CALTECH
Success story - Analyzing plant science processes at University of Manchester
Success story - Probing novel therapeutics possibilities at University of Western Australia
White paper - A new approach unveils drug targets inside the “black box” of the cell
查看最近的网络研讨会
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Revealing the intracellular distributions of biomolecules with a novel NanoSIMS-based methodology
星期二, 六月 18, 2024
Melanie Brunet, Ph.D. candidate in the Department of Chemical and Biomolecular Engineering at the University of Illinois Urbana−Champaign, working under the guidance of Prof. Mary Kraft, will introduce you to new NanoSIMS-based methodology that significantly enhances the accuracy of intracellular biomolecule visualization.
Key take aways include:
• Advanced Depth Correction
• Accuracy in Imaging
• Validation and Impact
• Research Applications.
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↓ Duration: 30 minutes
Click here to view
Improving the targeting of ASO therapeutic by NanoSIMS sub-cellular imaging
星期五, 二月 23, 2024
Cécile Becquart, post-doctoral fellow at AstraZeneca, presents recent advances in Antisense Oligonucleotides (ASOs) and the use of NanoSIMS to image and quantify the distribution and accumulation of ASOs within cells.
Key take aways include:
• Review challenges in terms of delivery of ASOs to specific tissues and inefficient escape from endolysosomal compartments which restrict their use in the clinic
• Understand the mechanisms underlying how ASOs enter cells and exit the endolysosomal space
• Learn about the specifics NanoSIMS sub-cellular quantitative imaging
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↓ Duration: 18 minutes
Click here to view
Lithium-ion battery research with NanoSIMS
星期五, 三月 1, 2024
Gina Greenidge, Higher Scientist at the National Physical Laboratory (NPL), UK’s National Metrology Institute, presents a study nitrogen fixation in maize leaf chloroplasts, or the role of vitamin B5 on cancer tumor proliferation.
Key take aways include:
• Review the capabilities of the NanoSIMS for nanoscale chemical mapping in LIB samples
• Observe the collocation of fluorine and phosphorus, and the increase in Li, P and F signals for aged LIB samples
• Gain insight into LIB anode degradation processes and the challenges that lie ahead for enabling batteries with longer life-time and higher performane
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↓ Duration: 32 minutes
Click here to view
Unveiling drug targets inside the “black box” of the cell with NanoSIMS
星期三, 二月 8, 2023
In this webinar Michael Kurczy discusses the development of the DrugSIMS™ platform. From the original blue sky initiative to embed a NanoSIMS in a pharmaceutical company to the eventual intracellular quantification of nucleic acid based therapeutics.
↓ Duration: 18 minutes
Click here to view
Subcellular measurements of cell turnover and metabolism with NanoSIMS
星期三, 八月 31, 2022
Pr. Steinhauser reports on his investigation of metabolic processes including glucose, lipid and nucleic acid metabolism, and cell turnover with NanoSIMS.
↓ Duration: 49 minutes
Click here to view
NanoSIMS Imaging of the Brain in Health and Disease
星期五, 六月 3, 2022
In this webinar, Dr Silvio Rizzoli will present NanoSIMS Imaging of the Brain in Health and Disease.
↓ Duration : 41 minutes
Click here to view
视频 +
A knew kind of invisible gold in pyrite
Learn from Denis Fougerouse how two CAMECA instruments contributed to the discovery of a new kind of “invisible gold”!NanoSIMS 50L ion microprobe at The University of Western Australia and the LEAP 3D Atom Probe Curtin University enabled to locate gold in pyrite crystals’ nanoscale defects - dislocations that are 100 000 times smaller that the width of a human hair!
NanoSIMS遍布全球的用户
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Below are links to some of our NanoSIMS Users
If your site is not listed and you would like to appear on this page, please contact cameca.info@ametek.com.
Stanford Nano Shared Facilities (SNSF), CA, USA
NSF provides shared scientific instrumentation, laboratory facilities, and expert staff support to enable multidisciplinary research and educate tomorrow’s scientists and engineers.
NASA, Astromaterials Research & Exploration Science, Houston TX, USA
The ARES scientists are dedicated to astromaterials research (meteorites, cosmic and interplanetary dust, solar wind, and lunar rocks), exobiology & organic geochemistry. They use a NanoSIMS 50L to uncover insights on processes of early solar system and stellar evolution.
Lawrence Livermore National Laboratory, California, USA
The NanoSIMS at LLNL is used in groundbreaking microbiological research: it helps studying microbial nitrogen and carbon fixation, and carbon cycling, investigating forensic signatures in bacterial spores, vegetative cells, viruses, as well as a range of nuclear materials..
CalTech Center for Microanalysis, USA
The Center for Microanalysis at Caltech houses a NanoSIMS 50L and an IMS 7f-GEO, providing expertise for microanalysis of geological, meteoritic and synthetic materials. Research projects carried out at CCM are most varied, ranging from cosmochemistry to experimental studies on climate change, geochronology, in-situ studies of microbial communities, materials science engineering, and more...
Center for NanoImaging, Brigham and Women's Hospital, USA
Our mission is to extend multi-isotope imaging mass spectrometry – or MIMS – to new areas of biology and biomedical research, including with human translational studies conducted at the Brigham and Women’s Hospital and collaborating medical centers.
Arizona State University, Tempe, USA
Funded by the National Science Foundation and ASU, the NanoSIMS lab at ASU is mainly in space sciences, to investigate the chemistry of asteroids and comets.
Washington University in Saint-Louis, MI, USA
The Laboratory for Space Sciences at Washington University received the first NanoSIMS in 2000. Research projects cover presolar grains, interplanetary dust particles, meteorite geochemistry etc.
Environmental Molecular Science Laboratory, Richland, WA, USA
EMSL, a national scientific user facility at Pacific Northwest National Laboratory has been equipped with a NanoSIMS 50L model since 2011.
Manchester University, School of Materials, UK
The NanoSIMS 50L is a major component of the Multi-Disciplinary Characterisation Facility, and is applied across a wide range of projects in advanced materials research, geological investigations of interest to the nuclear,oil and gas sectors, as well as the study of extra-terrestrial materials, but also tracing biochemical processes in microbes and plants.
Open University, UK
The NanoSIMS 50L lab in Milton Keynes is managed by Dr I.A. Franchi, and used primarily for characterizing fine grained material and cometary dust particles collected in the stratosphere.
The Department of Materials, University of Oxford, UK
The CAMECA NanoSIMS 50 is an ultra high resolution chemical imaging facility combining the sensitivity of a dynamic SIMS with a lateral resolution of about 100nm. Our machine was delivered in August 2002 and is used on a very wide range of projects in the analysis of metallic, semiconducting, polymeric and biological materials....
National Physical Laboratory (NPL), UK
NPL is home to the National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI), which aims to advance the development, understanding and application of the principal mass spectrometry imaging techniques. NPL researchers use the NanoSIMS 50L to support customers in healthcare, life sciences and other industries.
Max Planck Institute for Chemistry, Cosmochemistry Department, Mainz, Germany
The Cosmochemistry Department consists of several groups of scientists and technical personnel whose research interests and activities span a wide variety of fields in cosmochemical and space sciences. Many abstracts in the astrophysics field, downloadable in pdf format
Max Planck Institut, Bremen, Germany
The Max Planck Institute for Marine Microbiology of Bremen hosts the first NanoSIMS dedicated to environmental microbiology.
Leibniz Institute for Baltic Sea Research (IOW), Warnemünde, Germany
The NanoSIMS 50L at IOW is applied to a wide range of research fiels from microbiology and medicine to particle analysis and soil science.
TUM: Technische Universität München, Germany
Research Department Ecology and Ecosystem Management. Soil is the focal and connecting link between the information, matter and energy cycles of the hydrogeosphere and the atmosphere. Soil organic matter, clay sized particles and iron oxides are the most important reactants in soils building a complex physico-chemical interface. (…)
Helmholtz Centre for Environmental Research – UFZ Leipzig, Germany
Department of Isotope Biogeochemistry.
What is the role of biogeochemical processes in the functionality of sustainably managed ecosystems? How can stable isotope readings assist the understanding of the fate of chemicals in anoxic environments such as soil-aquifer systems, freshwater and deep-sea sediments and bioreactors?
University Medical Center Goettingen (UMG), Germany
The University of Göttingen NanoSIMS was acquired in 2017 to equip the Center for Biostructural Imaging of Neurodeegneration (BIN).It is mainly applied to the imaging of specific biological organelles, and thus provides insights into local protein and organelle turnover in a variety of cells and tissues.
Faculty of Life Science, University of Vienna, Austria
Inaugurated in February 2010, the NanoSIMS 50L lab is located within the Core Facility for Advanced Isotope Research. Under leadership from Michael Wagner, the Department of Microbial Ecology is one of the world leading center for single cell microbiology and the study of microorganisms in selected ecosystems.
UPFL: Université Polytechnique Fédérale de Lausanne, Switzerland
Laboratory for Biological Geochemistry LGB. Established in 2012, the LBG currently consists of about 15 Senior Scientists, Postdocs, PhD- and Master students working on research projects at the interface between isotope geochemistry, mineralogy and biology.
LIST, Luxembourg institute of Science and Technology, Luxembourg
The Luxembourg Institute of Science and Technology (LIST) is a mission-driven Research and Technology Organisation (RTO) that develops advanced technologies and delivers innovative products and services to industry and society.
Utrecht University, Netherlands
Since summer 2013 Utrecht University hosts the Dutch national facility for high-resolution in situ isotope and element analysis of natural materials, supporting research in biogeochemistry and (microbial) ecology, paleo-environmental and climate reconstructions, planetary and solid earth sciences.
> Watch video on NanoSIMS
Institut de Minéralogie, de Physique des Matériaux et de Cosmochimie (IMPMC), Paris, France
The IMPMC is particularly notable in its multidisciplinary approach. This means most topics are studied by researchers from different backgrounds—in physics, Earth science or biology. Experimental platforms, technical know-how and scientific expertise are all used to conduct research on the interactions between the living world (including bacteria) and the mineral world.
Institut Curie, Orsay, France
Analytical Imaging of the Cell by Secondary Ion Mass Spectroscopy (SIMS microscopy). Introduction: "Of the various analytical methods developed in microscopy during the latter half of the century, SIMS imaging is probably one of the most powerful and sophisticated. Originally introduced..." Link to full article.
Groupe de Physique des Matériaux (GPM), Rouen, France
The NanoSIMS at GPM supports multidisciplinary projects in the field of health and environment: human exposure to nanoparticles and their dispersion in the environment, interactions of (nano)particles with living organisms in connection with toxicological and cosmetological studies.
IPREM, Université of Pau, France
The NanoSIMS 50L at Institute of Analytical Sciences and Physico-Chemistry for Environment and Materials (IPREM) is the first one equipped with the new RF Plasma oxygen ion source. It is mainly used for the localization of metals at catalyst surfaces or the imaging of essential and toxic trace metals in biological cells.
Chemical Imaging Infrastructure of the Gothenburg University and Chalmers University of Technology, Sweden
The NanoSIMS 50L in Gothenburg is the first of these instruments in Scandinavia. The NanoSIMS is suitable for a wide variety of applications such as grain boundary analysis, characterization of stress corrosion cracking, sub-cellular drug/peptide imaging and nitrogen fixation studies in bacteria.
Physical Research Laboratory, India
Known as the cradle of Space Sciences in India, the Physical Research Laboratory (PRL) was founded in 1947 by Dr. Vikram Sarabhai. As a unit of the Department of Space, Government of India, PRL carries out fundamental research in select areas of Physics, Space & Atmospheric Sciences, Astronomy, Astrophysics & Solar Physics, and Planetary & Geosciences.
IGGCAS, Beijing, China
The Institute of Geology and Geophysics, Chinese Academy of Sciences houses a NanoSIMS 50L in addition to its 2 large-geometry SIMS (IMS 1280 and IMS 1280-HR). The NanoSIMS was acquired to promote research in space sciences and is meant to play a major role in the analysis of lunar samples retrieved by Chinese lunar exploration missions.
Academia Sinica, Taipei, Taiwan
The NanoSIMS Laboratory was established in 2013 by a cooperative effort between Institute of Astronomy and Astrophysics and the Institute of Earth Science of Academia Sinica. Primarily designed to probe the early Solar System by analyzing extraterrestrial and terrestrial samples, the laboratory is also involved in numerous interdisciplinary collaborations with both domestic and international research groups covering cosmo, geo, life and material sciences.
Kochi Institute for Core Research Sample, JAMSTEC, Japan
The Isotope Geochemistry Group owns several CAMECA SIMS dedicated to the analysis of isotopes and trace elements in geological, environmental and biological samples to understand water-rock interactions, geologic processes, global & regional geochemical cycles, and limits of subseafloor life.
Toray Research Center, Japan
Established in 2018, the NanoSIMS 50 L lab offers analytical service in semiconductor, ceramics, metal and life science areas.
Centre for Microscopy, Characterization & Analysis, UWA, Perth, Autralia
Established in 1970, the CMCA provides essential teaching and research infrastructure in ion, electron, laser and light microscopy and microanalysis to universities, goverment of Western Australia and local industry. It is now home to two CAMECA ion probes, the NanoSIMS 50 installed in 2003 and the more recently acquired IMS 1280.
软件
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WinCurve
WinCurve专为CAMECA SIMS仪器而开发，可在用户友好的环境中提供强大的数据处理和可视化功能。
继续阅读
WinImage II
WinImage II专为CAMECA SIMS仪器而开发，可在PC-Windows™环境中提供强大的数据处理和可视化功能。
继续阅读
APM
自动颗粒测量（APM）是CAMECA推出的一款软件工具，可应用于数百万颗粒的快速筛选、颗粒探测和同位素表征。
继续阅读
NanoSIMS出版物
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现有引用NanoSIMS数据的科学研究文章的汇总Excel电子表格可供下载。这些文章按以下主要应用领域进行分类，并且可以使用Excel字词搜索功能轻松搜索：
大气颗粒/气溶胶
生物矿化/古气候
细胞生物学
环境微生物学
地质学/环境学
地质年代学
古生物学/进化论
化妆品和药理学
行星科学
植物
土壤
材料
仪器/方法学
点击此处下载电子表格：NanoSIMS科学文章汇总。
如果您无法打开部分PDF文件，请随时通过电子邮件（cameca.info@ametek.com）联系我们。如果您有其他相关参考资料、PDF和补充信息，请发送给我们！
升级套件
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PRIMARY COLUMN
RF-plasma O-：高亮度O-主离子源
替换duoplasmatron O-离子源。 RF等离子体离子源的较高亮度允许获得与Cs +源相似的O-束密度和横向分辨率。
D1 5-Slits_NS：五个D1光圈隔膜狭缝
物镜/浸没式镜头光圈带通过增加4到5种尺寸的直径选择来增加灵活性。
EXLIE Pre-implant_NS：极低的冲击能量
超低能量（25-500eV）样品轰击允许预植入/清洁而不消耗超薄样品的顶部表面。
高电流Column_NS：高电流初级离子柱
允许更大的最大Cs +电子束电流（最高20nA而不是几个nA）。
使用更大的电流允许使用多个FC代替EM并提高同位素比重现性。
真空
Pfeiffer Turbo：更换三个涡轮分子泵
用同等的Pfeiffer型号替换三个涡轮分子Varian / Agilent泵，具有出色的可靠性。
加载锁定生产力增强：如果加载锁定
替换标准涡轮泵/>
对于需要非计划加载和快速分析的实验室，可以用300 l / s涡轮分子泵代替标准的80 l / s负载锁定涡轮泵。然后，在负载锁定中达到1E-6mbar所需的时间通常从~120分钟减少x3。到~40分钟。
质量分析器
EM前置放大器Gen2_NS：五个新的EM前置放大器鉴别器
用于离子计数的电子离子脉冲放大的改进。
更可靠的设置和鉴别器/阈值的调整，以获得更可重复的同位素比率。
内部Multico Gen2_NS：新内部多重收藏
可移动电缆提高了可靠性，减少了短路和堵塞。
低噪声前置放大器_NS：Multico Geo Faraday：用于FC＃1的低噪声前置放大器
精确的FC-EM同位素比率。
法拉第杯具有更低的噪声/背景，从而在FC中实现更好的重现性和更大的电流检测范围。
Multico Triple Faraday_NS：Multicollection triple Faraday
三个FC而不是一个。
允许测量具有亚permil再现性的多个FC中的同位素比率，通常记录具有更高（几个nA）和<微米; m点。
NMR H / D_NS: 氢的附加NMR探针
低质谱线的稳定性。
添加了第三个专用的NMR探针，提高了分析仪磁场的稳定性，实现了H比率的高再现性。
IMAGING
SED_NS: 二次电子探测器
二次电子成像，用于定位小颗粒和良好的对比度，以补充SIMS成像。
电子
32b_Acquisition Board_NS：32位计数板
取代16bit以前的版本，是使用Team Viewer通过互联网进行远程控制所必需的。
SIMS图像不再饱和，扫描速度更快，充电问题更少。
数据系统
PC automation_NS：PC Windows Control升级
不再支持SUN系统，取而代之的是PC Windows自动化。
PC版本下可用的新功能。
软件版本Update_NS: 更新后的软件版本
最新的PC自动化版本，用于删除问题，新功能以及某些升级所需的版本。
Control Duplication_NS：NanoSIMS控件的复制
从两个房间内的CAMECA设计的键盘，从单独的操作室（<15 m）控制仪器。
允许优化的操作舒适性（降低噪音，单独的T＆deg; C控制）
其他WinImage II_NS：其他64位WinImage II离线PC软件许可证
SUN和PC数据的图像处理。适用于多个用户的加密狗。
自动化
DUO Auto Valve_NS：Duoplasmatron泄漏阀的自动化
允许在无人值守采集结束时关闭泄漏阀，使用duoplasmatron在拆卸清洁时更长时间使用双源。
Full MDA_NS：Aperture和Hexapole Automation
狭缝自动化＆amp;用于提高再现性的孔径，低级别用户的访问，清洁/获取的链接，使用的舒适性。＆nbsp;
样品持有人，SHUTTLES＆amp;转移
Sample-holders_Shuttles_NS：样品架和航天飞机的列表可在此链接获得。
请联系售后服务部门获取订单。
磁力转移棒：两个磁力传递杆
将带有样品架的梭子从装载锁转移到分析台上。
您还可以查看适用于您的乐器的软件版本。
不要犹豫，联系您的本地代理商或＆CAMECA销售部门了解更多信息。